ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
Biodistribution of Technetium- 99m Labeled Diltiazem and Nifedipine in Normal Mice [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1993; 6(1): 59-62

Biodistribution of Technetium- 99m Labeled Diltiazem and Nifedipine in Normal Mice

Meral T. Ercan1, Tulin Aras2, Nail Çaglar3
1From Department of Nuclear Medicine, Medical Faculty, Hacettepe University, 06100 Sihhiye, Ankara, Türkiye.
2From Department of Cardiology, Medical Faculty, Hacettepe University, 06100 Sihhiye, Ankara, Türkiye.
3From Medical Faculty, Ankara University, Ibni Sina Hospital, 06100 Sihhiye, Ankara, Türkiye.

Diltiazem and nifedipine were labeled with 99mTc by Sn++ reduction method with an efficiency of greater than 99% as determined by ITLC. The biodistribution of both agents were studied in normal mice at various intervals. Scintigrams were also obtained at 1 hour post-injection of mice and at 30 min intervals up to 3 hours in rabbits. Our results indicated a very high accumulation in liver (max. 61.4±10.0 %/g for 99mTc-diltiazem and 36.1±0.6 %/g for 99mTc-nifedipine) with negligible uptake by other organs in mice. Chromatographic analyses of urine samples indicated excretion of a soluble metabolite of 99mTc-diltiazem in high quantity (89.6±3.6 % of the total radioactivity in the urine). Because of high liver accumulation and no selective uptake in myocardium (max. 0.72±0.01 %/g for 99mTc-diltiazem and 0.312±0.224 %/g for 99mTc-nifedipine) the labeled compounds cannot be used for the scintigraphic visualization of myocardium.

Keywords: 99mTc-diltiazem, 99mTc-nifedipine, ITLC, scintigraphy.


Meral T. Ercan, Tulin Aras, Nail Çaglar. Biodistribution of Technetium- 99m Labeled Diltiazem and Nifedipine in Normal Mice. Med J Islamic World Acad Sci. 1993; 6(1): 59-62

Corresponding Author: Meral T. Ercan, Türkiye


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