Effect of Smoking on Leptin Concentration in Normal Subjects and during Acute Myocardial Infarction

The purpose of this study was to measure leptin concentrations in the blood of smokers and non smokers during ST elevation acute myocardial infarction, and to compare them with values obtained from normal smoker and non smoker subjects. Leptin serum concentrations were measured in 58 patients (34-75 years of age) with acute myocardial infarction and 38 normal subjects (36-69 years of age). Leptin serum concentrations were measured using two-site immunoradiometric assay (IRMA) principle. In normal smokers (N=20) leptin concentration was 5.8 ± 2.5 ng/ml (mean ± SD), while in non smokers (N=18) this value was 5.9 ± 4.1 ng/ml (mean ± SD). Data showed no significant difference in both groups (p > 0.05). While leptin concentration was 7.8 ± 2.9 ng/ml in smoker patients (N=32) which was significantly higher than in normal smoker subjects (p=0.02). Also leptin value was 9.2 ± 3.7 ng/ml in non smoker patients (N=28) which was also significantly higher than in normal non smoker subjects (p=0.001). Our results demonstrated that smoking has no effect on leptin concentrations in normal subjects and in patients with acute myocardial infarction, but leptin concentration increases significantly during ST elevation acute myocardial infarction in smoker and non smoker patients.