ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
Reversibility of Age-Related Immune Dysfunction in Mammals by A Combined Treatment of Some Trace Elements and Vitamins [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2006; 16(3): 103-114

Reversibility of Age-Related Immune Dysfunction in Mammals by A Combined Treatment of Some Trace Elements and Vitamins

Kamal A. El-Shaikh, Mohamed S. Gabry, Gehan A. Othman
Department Of Zoology, Faculty Of Science, Helwan University, Cairo, Egypt.

Immune responses normally reduced during aging may be resulted to different extends by the intake of several essential micro- and macronutrients. The aim of the present study was to investigate the in vivo effect of different doses of hepanox on humoral and cell mediated immune responses of aged-mice in a trial to improve age-associated immune dysfunction.
Different doses of hepanox (0.4, 2 or 10 g/mouse) were orally administrated to aged mice daily for one month. Control mice were treated with 0.2 ml of the sesame oil only. Our study shows that total leukocyte counts from PBL, Thy, PLN, MLN and BM as well as total and differential counts of PEC were significantly decreased in aged mice. Treatment of aged mice with hepanox preparations (0.4, 2 or 10 g/mouse) caused a progressive increase in the total numbers of leukocytes from all lymphoid organs studied.
The present study shows also that the phagocytic function of PEC decreased with age of mice, while treatment of aged mice with hepanox preparation elicited a progressive increase in the scavenger activity of PEC. In old mice, there is a significant decline in PFC response to in vivo immunization with SRBC while the treatment of aged mice with hepanox preparation elicited a gradual increase in PFC response. Also, the number of T-lymphocytes decreased significantly with advancing age of mice. Treatment of aged mice with hepanox preparations (2 and 10 g/mouse) elicited a progressive increase in the number of T-lymphocytes. While in vitro addition of hepanox preparations (0.002, 0.01 or 0.05 g/well) to old mice splenocytes, stimulated with Con A mitogen, significantly increased T-cells proliferation. The treatment of aged-mice with hepanox might be capable of maintaining and restoring the aged-related reduction in the immune efficiency.

Keywords: Hepanox, aging, lymphocytes, immunization, immune efficiency.


Kamal A. El-Shaikh, Mohamed S. Gabry, Gehan A. Othman. Reversibility of Age-Related Immune Dysfunction in Mammals by A Combined Treatment of Some Trace Elements and Vitamins. Med J Islamic World Acad Sci. 2006; 16(3): 103-114

Corresponding Author: Kamal A. El-Shaikh, Egypt


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 











 
Copyright 2019 medicaljournal-ias.org. All Rights Reserved.