A Study on Serum Proteins in Diabetic and Non-Diabetic Pregnant and Menopausal Women of Two Socio-Economic Statuses

Present study was carried out on 160 women belonging to Faisalabad region (Pakistan) including diabetic and non-diabetic and as well as pregnant and menopausal women in equal number. These women were randomly selected from those coming to various hospitals of the city. Blood samples from these subjects were collected with and without anticoagulant to obtain plasma and serum for further studies. Study revealed serum total proteins to be 4.49, 5.55, 4.73 and 5.31 g/100 ml and albumin 3.35, 4.21, 3.74 and 3.80 g/100 ml in pregnant, menopausal, diabetic and non-diabetic groups, respectively. Serum globulins were 1.15, 1.34, 0.99 and 1.50 g/100 ml and serum immunoglobulins were 130.20, 150.95, 92.15 and 189.96 zst-units, respectively. Plasma fibrinogen was 292.68, 497.50, 353.66 and 435.00 mg/100 ml in four groups. Comparison of different serum proteins between diabetic and non-diabetic women revealed significant (p<0.05) difference only in immunoglobulins which were higher (p<0.05) in non-diabetic women, while comparison between pregnant and menopausal women revealed significant (p<0.05) difference in plasma fibrinogen concentration which was higher in menopausal women. When diabetic pregnant, diabetic menopausal, non-diabetic pregnant and nondiabetic menopausal women were compared, values for serum total proteins, albumin, globulins, immunoglobulins and fibrinogen were higher (p<0.05) in non-diabetic menopausal subjects. Nonsignificant difference was observed in serum total proteins and fractions between women of two socioeconomic statuses (SES) in each group.