ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
The Median Raphe Nucleus Lesion Attenuates Amnesic Effects of Ketamine on Short-Term Memory in Rats [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1994; 7(4): 241-246

The Median Raphe Nucleus Lesion Attenuates Amnesic Effects of Ketamine on Short-Term Memory in Rats

Emine Babar1, Tuncay Özgünen1, Enver Melikov2, Sait Polat3, Mehmet Kaya3
1From Department of Physiology, Medical Faculty, Çukurova University, Adana, Türkiye.
2From A.I. Garayev Institute of Physiology Azerb Acad Sci, Baku, Azerbaijan.
3From Department of History, Medical Faculty, Çukurova University, Adana, Türkiye.

The effects of pre-anesthetic dose of ketamine (10 mg per kg) on acquisition of short-term memory in rats with damage of mesolimbic serotonergic system has been investigated. Chemical lesion of serotonergic neurons in the median raphe nucleus was performed by ibotenic acid. The rats injected ketamine (10 mg per kg i. p.) or vehicle (1 ml per kg i. p.) prior to learning were tested after changes in locomotor activity disappeared. Short-term memory was studied using a two compartment single trial passive avoidance chamber for 180 s. In rats with lesion of median raphe nucleus, the pre-anesthetic dose of ketamine produced a significant decrease reduction of acquisition latencies and percentage of animals without amnesia syndrome compared to naive and sham-operated animals-treated with ketamine. These result suggest that deficits in serotonin release of mesolimbic system attenuates amnesic effects of ketamine on short-term memory.

Keywords: Ketamine, short-term memory, serotonin, median raphe nucleus lesion.


Emine Babar, Tuncay Özgünen, Enver Melikov, Sait Polat, Mehmet Kaya. The Median Raphe Nucleus Lesion Attenuates Amnesic Effects of Ketamine on Short-Term Memory in Rats. Med J Islamic World Acad Sci. 1994; 7(4): 241-246

Corresponding Author: Emine Babar, Türkiye


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