ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
Safety Test On Mice with Bacillus Thuringiensis Isolate [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1990; 3(1): 35-40

Safety Test On Mice with Bacillus Thuringiensis Isolate

Lutfu Çakmakçı, Nurdan Özer, Bulent Alten, Nacı M. Bor, Selma Yorukan, Ayse Bosgelmez, Oner Kocak, Behzat Gürkan, Olus Karayalcın, Esın Alten, Feriha Gürkan
Scientific and Technical Research Council of Turkey (TOAG-TARMIK) and was conducted at the Surgical Reseach Center, Hacettepe University Medical School, Ankara, Türkiye.

The toxicological studies performed on Bacillus isolate 310109 isolated from the Iskenderun region of Turkey, by experimental infection of mice have revealed the absence of acute and prolonged toxicity. All acute and prolonged toxicity tests produced negative results with all the various routes, subcutaneous, intraperitoneal, intravenous injection oral (gavage), inhalation and percutaneous application and eye irritation test, using 2x108 bacteria per/ml suspension for each inoculation. Neither pathological symptoms nor mortality were observed. The behaviour and weight gain of the experimentally infected animals were within the normal range and close to those of the control animals.

Keywords: Safety tests, biological control, Bacillus thuringiensis.


Lutfu Çakmakçı, Nurdan Özer, Bulent Alten, Nacı M. Bor, Selma Yorukan, Ayse Bosgelmez, Oner Kocak, Behzat Gürkan, Olus Karayalcın, Esın Alten, Feriha Gürkan. Safety Test On Mice with Bacillus Thuringiensis Isolate. Med J Islamic World Acad Sci. 1990; 3(1): 35-40

Corresponding Author: Lutfu Çakmakçı, Türkiye


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