ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
Mercury(II) Cystine Complex as Antineoplastic Agent [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2009; 17(2): 81-86

Mercury(II) Cystine Complex as Antineoplastic Agent

M. M. Ali1, M. Jesmin1, S. M. A. Salam1, M. R. Habib2, J. A. Khanam2
1Department of Applied Chemistry and Chemical Technology, Rajshahi University, Rajshahi-6205, Bangladesh.
2Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205, Bangladesh.

Antineoplastic activity of mercury(II) cystine complex was studied against ehrlich ascites carcinoma (EAC) cells in Swiss Albino mice. Cell growth inhibition, increase of life span, haematological parameters, alkaline phosphatase activity of tumour bearing mice inoculated with EAC cells were studied with the test compound. It was found that this compound significantly inhibited the tumour cell growth, enhanced life span of the tumour bearing mice at dose 6 mg/kg i.p. Such treatment also restored the altered haematological parameters and serum alkaline phosphatase activity very closely towards normal. The compound can be considered as a potent antineoplastic agent.

Keywords: Mercury(II) cystine complex, antineoplastic activity, ALK activity, EAC cells.


M. M. Ali, M. Jesmin, S. M. A. Salam, M. R. Habib, J. A. Khanam. Mercury(II) Cystine Complex as Antineoplastic Agent. Med J Islamic World Acad Sci. 2009; 17(2): 81-86

Corresponding Author: M. M. Ali, Bangladesh


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