ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 25 Issue : 4 Year : 2017
 
Thiol–disulfide Homeostasis in Acute Appendicitis [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2017; 25(4): 114-117 | DOI: 10.5505/ias.2017.78803  

Thiol–disulfide Homeostasis in Acute Appendicitis

Yücel Yüzbaşıoğlu1, Güllü Ercan Haydar2, Yavuz Otal2, Serpil Erdoğan3, Salim Neşelioğlu3, Aydan Kılıçarslan4, İbrahim Kılınç5, Yunus Emre Arık2
1Department of Emergency, University of Health Sciences Keçiören Training And Research Hospital, Keçiören, Ankara, Turkey.
2Department of Emergency, Yıldırım Beyazıt University Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey.
3Department of Biochemistry, Yıldırım Beyazıt University Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey.
4Department of Pathology, Yıldırım Beyazıt University Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey.
5Department of General Surgery, Yıldırım Beyazıt University Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey.

This study aimed to assess the diagnostic value of thiol–disulfide homeostasis in patients with acute appendicitis (AA). A total of 43 patients diagnosed with acute appendicitis in the emergency department and 59 healthy individuals were evaluated. Age, gender, white blood cell count, and thiol–disulfide homeostasis parameters (native thiol, total thiol, disulfide, disulfide/native thiol, native thiol/total thiol, and disulfide/total thiol ratios) were compared between groups. Thiol–disulfide homeostasis was determined using a newly developed method by Erel and Neşelioğlu. White blood cell counts were statistically significantly higher in the AA group, but no significant difference (P = 0.742) was found between native thiol, total thiol, and disulfide levels of the patient and control groups. Also, no statistically significant difference was observed in disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios (P = 0.117) between groups. This was thought to be a result of early diagnosis of AA in patients at the emergency department. Hence, the inflammatory response did not increase significantly at the time of diagnosis.

Keywords: Appendicitis, oxidative, stress, thiols


Yücel Yüzbaşıoğlu, Güllü Ercan Haydar, Yavuz Otal, Serpil Erdoğan, Salim Neşelioğlu, Aydan Kılıçarslan, İbrahim Kılınç, Yunus Emre Arık. Thiol–disulfide Homeostasis in Acute Appendicitis. Med J Islamic World Acad Sci. 2017; 25(4): 114-117

Corresponding Author: Yücel Yüzbaşıoğlu, Türkiye


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