Design, Synthesis and Pharmacological Evaluation of N-Methyl Piperidine Derivatives

Piperidine is among the most important heterocyclic compounds which exhibits its therapeutic activity due to its conformationally flexible nature. Molecular modifications of meperidine and morphine like compounds led to the synthesis of analgesics having antagonistic properties with specific reference to Drug-Receptor Interaction. During the course of present investigations attempts were made to synthesize quaternary derivatives of N-methyl piperidine with various phenacylhalides and extensively explored for possible analgesic activity.
Spectrophotometric studies such as UV, IR, Mass (EI) and proton NMR were carried out to confirm the structures of newly synthesized derivatives in order to correlate the Structure Activity Relationship (SAR).