ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
The Effects of Vitamin E on Bodyweight and Fat Mass in Intact and Ovariectomized Female Rats [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2001; 14(4): 125-138

The Effects of Vitamin E on Bodyweight and Fat Mass in Intact and Ovariectomized Female Rats

A. Azman1, B.A.K. Khalid2, S. Ima-Nirwana1
1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
2Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

The aim of this study was to determine the effect of vitamin E deficiency and supplementation on body weight and body composition in intact and ovariectomized growing female rats. One hundred and twenty female Wistar rats aged 3 months were ovariectomized (OVX) or left intact (sham-operated). The intact and OVX rats were divided into 6 groups and given different dietary treatments, i.e. vitamin E deficient diets (VED, 75%VED, 50%VED, 25%VED), normal rat chow diet (RC) and rat chow with oral supplementation of 30mg/kg body weight of -tocopherol (RC+ATF). Body weight of intact and OVX rats in the RC and the RC+ATF groups showed increased significantly after 15 weeks of dietary treatment. Intact and ovariectomized rats fed with VED, 75%VED, 50%VED and 25%VED did not gain weight after 15 weeks. OVX rats had significantly higher body weight than intact rats in the 50%VED, 25%VED, RC and RC+ATF groups. Fat mass of intact rats was increased only in the RC and RC+ATF groups. For OVX rats, fat mass was increased in the VED, 50%VED, RC and RC+ATF groups. OVX groups had significantly higher fat mass when compared with intact groups, however, the significance was greater for the RC and RC+ATF groups. Other parameters of body composition were not significantly affected. In conclusion, vitamin E played an important role in the weight gain of female rats and the gain was primarily due to the increase in fat mass, irrespective of the effect of ovariectomy. Alpha-Tocopherol supplementation conferred little benefit compared to giving RC diet alone in both the intact and ovariectomized female rats. The results also indicate that excessive vitamin E intake might contribute towards obesity in female rats.

Keywords: Vitamin E, body weight, fat mass, ovariectomy.


A. Azman, B.A.K. Khalid, S. Ima-Nirwana. The Effects of Vitamin E on Bodyweight and Fat Mass in Intact and Ovariectomized Female Rats. Med J Islamic World Acad Sci. 2001; 14(4): 125-138

Corresponding Author: S. Ima-Nirwana, Malaysia


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