ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
Aluminium Interference with Iron Absorption by Everted Gut Sac [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1993; 6(4): 277-281

Aluminium Interference with Iron Absorption by Everted Gut Sac

A. A. Moshtaghie, M. Taher
From Department of Biochemistry, School of Pharmacy, Isfahan Medical Sciences University, Isfahan, Iran.

Iron absorption by everted gut sac (EGS) and the effect of aluminium in this process has been investigated. Incubation of freshly prepared rat EGS in Earle's medium pH=7.4 containing either Fe (II) and or Fe (III) showed that maximum absorption occurred within 30 min of incubation time. The absorption of Fe (II) or Fe (III) by EGS was dose dependent. Maximum absorption was carried out in the presence of 8 mM of iron followed by a gradual reduction thereafter. Aluminium (400 ug/1) reduced iron uptake by 24%. Apo-transferrin when saturated with aluminium (30-90%) and inserted inside the sac caused reduction in iron uptake. The higher the percentage of saturation the lower the iron uptake by EGS. Suggesting the probable role of transferrin in iron uptake. The mechanism of iron absorption by EGS and the effect of aluminium in this process has been discussed.

Keywords: Aluminium, iron, transferrin.


A. A. Moshtaghie, M. Taher. Aluminium Interference with Iron Absorption by Everted Gut Sac. Med J Islamic World Acad Sci. 1993; 6(4): 277-281

Corresponding Author: A. A. Moshtaghie, Iran


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