ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
Technetium-99m Citrate for Imaging Inflammation: An Experimental Study [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1992; 5(3): 180-188

Technetium-99m Citrate for Imaging Inflammation: An Experimental Study

Meral T. Ercan, Tülin Aras, Isıl S. Ünsal, Ünser Arıkan, Erkan Ünlenen, Zafer Hasçelik
From Departments of Nuclear Medicine, Pathology, and Physical Medicine and Rehabilitation, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkiye.

Citric acid was labeled with 99mTc by the Sn++ reduction method with an efficiency of >98%. The biodistribution of 99mTc-citrate was determined in mice with abscesses in their right thigh muscles and compared to 67Ga-citrate. The maximum abscesses/muscle ratios for 99mTc-citrate were 4.00±1.39 and 4.47±1.76 at 1 h for the turpentine- and Staphylococcus-induced abscesses, respectively. Corresponding values for 67Ga-citrate were 4.76±2.04 and 3.97±1.99 at 4 h. Arthritis was induced in 10 rabbits with intra articular injection of ovalbumin. Scintigraphic images obtained as a function of age up to 21 days showed increased activity involving the synovium. The maximum arthritic/contralateral knee ratio was 3.56±2.42 at 21 days. The blood clearance curve of 99mTc-citrate in rabbits was biexponential with a fast (T1/2=51 min) and a slow (T1/2=22 h) components. Analysis of urine samples indicated that most of the excreted radioactivity was due to intact 99mTccitrate (>95%), as determined by ITLC and electrophoresis. Our results demonstrated that 99mTc-citrate is a potential radio pharmaceutical for the visualization of inflammatory lesions.

Keywords: Inflammation, technetium-99m citrate, synovial scintigraphy.


Meral T. Ercan, Tülin Aras, Isıl S. Ünsal, Ünser Arıkan, Erkan Ünlenen, Zafer Hasçelik. Technetium-99m Citrate for Imaging Inflammation: An Experimental Study. Med J Islamic World Acad Sci. 1992; 5(3): 180-188

Corresponding Author: Meral T. Ercan, Türkiye


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