ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
Differential Effects of Morphine Sulphate on Phospholipid Species in The Synaptosomes of The Rat Brain [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2000; 13(1): 17-30

Differential Effects of Morphine Sulphate on Phospholipid Species in The Synaptosomes of The Rat Brain

Nagwa El-Mosallamy1, Ezzat El-Daly2, Shereen El-Kiki3
1Department of Zoology, Faculty of Science, Cairo University, Giza.
2Department of Zoology, Faculty of Science, Helwan University, Cairo.
3Department of Health Research, International Research Center of Radiation and Technology, Cairo.

Studies were carried out to explore the effect of acute and chronic administration of morphine sulphate and drug withdrawal on the concentrations of synaptosomal phospholipid species [phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and phosphatidylserine (PS)] in brain areas of adult male albino rats.
It was found that acute administration of morphine (35 mg/kg body weight) decreased concentrations of synaptosomal PC and PE in cerebellum and increased their levels in striatum. Conversely, PS and PI showed significant increases in cerebellum and significant decreases in striatum.
However, chronic administration of increasing doses (15-75 mg/kg body weight) of the drug decreased the concentrations of synaptosomal PE, PS and PI of striatum and PC in cortex.
Two days after morphine withdrawal the synaptosomal PC, PE, PS and PI showed significant increases in striatum and thalamus-hypothalamus. Conversely, PC and PE concentrations were decreased significantly in synaptosomes of cerebellum after two days of drug withdrawal. Also, after four days of morphine withdrawal, the synaptosomal PC and PE were diminished in cerebellum and increased in cortex.
Overall, the present results suggest that the mechanisms of opioid action are closely associated with changes in the turnover of the brain phospholipid species.

Keywords: Phospholipids, morphine sulphate, drug withdrawal.


Nagwa El-Mosallamy, Ezzat El-Daly, Shereen El-Kiki. Differential Effects of Morphine Sulphate on Phospholipid Species in The Synaptosomes of The Rat Brain. Med J Islamic World Acad Sci. 2000; 13(1): 17-30

Corresponding Author: Ezzat El-Daly, Egypt


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