ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
Volume : 27 Issue : 3 Year : 2019
Digoxin Compliance: A Pharmacokinetic Quantification [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2001; 14(3): 117-122

Digoxin Compliance: A Pharmacokinetic Quantification

Moneyreh Modares-Mosadegh1, Seyed M. Sadr Bafghi2
1Department of Pharmacology, College of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2Department of Internal Medicine, College of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

To quantify extent of compliance in patients receiving digoxin by implementing an applied pharmacokinetic approach and to determine the percentage of patients with levels within therapeutic range.
One hundred-nineteen patients, whom met the required criteria, were enrolled in this study. Based on their digoxin doses, they were divided into 4 groups. Group A took 1 tablet (0.25 mg) per day, group B received half a tablet (0.125 mg) each day, group C used 6 tablets per week, and group D took 5 tablets per week and two days were off the drug. A pharmacokinetic approach was used to predict the serum digoxin concentrations of patients and the expected levels were compared with the actual concentrations.
52.29% of patients were compliant. There was no significant difference between the compliant and non-compliant groups with regard to gender, age, and number of concurrent medications or duration of digoxin intake. However, with respect to their doses, a significant difference existed between 2 groups (p<0.01). Patients in group D were more compliant (80.56%). In addition, their serum digoxin concentrations were relatively more within the therapeutic range (89.66%). Therefore, patients with the lowest frequency of digoxin intake were more compliant.
The results of this study indicate that a considerable number of patients do not take digoxin as directed. Patients with the least frequency of digoxin intake were relatively more compliant.

Keywords: Digoxin, concentration, compliance, pharmacokinetics.

Moneyreh Modares-Mosadegh, Seyed M. Sadr Bafghi. Digoxin Compliance: A Pharmacokinetic Quantification. Med J Islamic World Acad Sci. 2001; 14(3): 117-122

Corresponding Author: Moneyreh Modares-Mosadegh, Iran

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