Hypophysis-Adrenal System and Immunologic Status of Patients with Idiopathic Thrombocytopenic Purpura

A series of 62 patients, l7 males and 45 females with idiopathic thrombocytopenic purpura and 35 patients forming the control group were studied. All patients were given glucocorticosteroid hormones. The first group of patients sensitive to hormone revealed endogenic cortisol levels above normal before therapy. Hypercortisolemia was observed in the cases with severe, mild or intermediate forms of disease along with complete compensation under GCH therapy. These patients produced adequate reaction to stress, cortisol activation in pathologic process with mobilization of the preventation forces for elimination of unnecessary agents. In all ITP cases with response to hormone therapy (group I) endogenic cortisol values reached to immunodepressive levels.