Study of Blood Pressure Patterns Versus Serum Lipid Parameters in Obese Human Subjects

A study was conducted to determine relationship of obesity with the blood pressure patterns and lipid parameters in preview of its unique local diet patterns. A total of 200 non-diabetic human subjects of either sex were included in the study. They were categorized on the basis of body mass index (BMI) as obese and non-obese. Each group was further divided into 2 subgroups; hypertensive and normotensive. Fasting lipid profile (total cholesterol, LDL-and HDL-Cholesterols and total triglycerides) in each group was determined to compare the levels among various groups. BMI was calculated from height and weight, while blood pressure was measured with a sphygmomanometer. Lipid profile was determined with Merck kits. Diet and related information was also collected from the patients directly.
Means of all parameters, except LDL-C, were higher in females than males; among these BMI and HDL-C showed significant difference. There was a significant negative correlation of diastolic blood pressure with HDL-C in obese subjects; all the other parameters were non-significantly correlated. In the non-obese subjects, there was a significant positive correlation between systolic (SBP) and diastolic (DBP) blood pressures and LDL-C. All other parameters were found non-significantly correlated. The analysis of variance was done in four groups namely, obese non-hypertensives, obese hypertensives, non obese non-hypertensives and non obese hypertensives. BMI, SBP, DBP, LDL-C and total cholesterol had significantly different means in the above four groups, while HDL-C and total triglycerides were statistically non-significant (p>0.05) among four groups.