ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
Ultra-Structure of The Liver in Propylthiouracil Induced Hepatitis [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1993; 6(4): 268-276

Ultra-Structure of The Liver in Propylthiouracil Induced Hepatitis

Ufuk Ö. Mete1, Mehmet Kaya1, Salih Çolakoglu2, Sait Polat1, Özgür Tap1, M. Kemal Özbilgin1, G. Özgür2
1From Department of Histology-Embryology, Faculty of Medicine, University of Çukurova, Balcali, Adana, Türkiye.
2From Department of Internal Medicine, Faculty of Medicine, University of Çukurova, Balcali, Adana, Türkiye.

A case of cholestatic hepatitis occurring in a 50 year old woman treated with propylthiouracil for 1.5 months is presented. Physical examination showed generalized icterus and nodular goiter. Electron microscopic examination of liver biopsy revealed dilated smooth and rough endoplasmic reticulum, mitochondrial inclusions, excessive lipofuchsin granules and vacuolar formation both in the cytoplasm and nucleus of the hepatocytes. The ultrastructural changes in the liver have never been described in detail in propylthiouracil induced hepatitis previously. In this article the possible pathophysiology of the disease is discussed.

Keywords: Propylthiouracil, liver, electron microscopy.


Ufuk Ö. Mete, Mehmet Kaya, Salih Çolakoglu, Sait Polat, Özgür Tap, M. Kemal Özbilgin, G. Özgür. Ultra-Structure of The Liver in Propylthiouracil Induced Hepatitis. Med J Islamic World Acad Sci. 1993; 6(4): 268-276

Corresponding Author: Ufuk Ö. Mete, Türkiye


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