ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
Effect of Benzene on Drug Metabolizing Enzyme Activities of Lung and Liver Microsomes [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1988; 1(1): 31-34

Effect of Benzene on Drug Metabolizing Enzyme Activities of Lung and Liver Microsomes

Emel Arınç, Mesude Iscan, Orhan Adalı, Tülin Güray
From Department of Biological Sciences Middle East Technical University, Ankara, Türkiye.

In vivo treatment of rabbits with benzene (880 mg/kg, s. c., 3 days) caused 7. I-fold increase in hydroxylation of p-nitrophenol to 4-nitrocatechol in liver microsomes. A 3.7 fold increase was also observed in liver aniline 4- hydroxylation activities. Benzene treatment did not cause any significant changes on drug metabolizing enzyme activities of lung microsomes. Although benzene treatment did not change cytochrome P-450 contents of lung and liver microsomes, it caused 1 nm spectral shift in the absorption maxima of CO difference spectrum of the dithionote reduced liver cytochrome P-450 forming cytochrome P-451.

Keywords: Benzene, drug metabolizing enzymes, mixed-function oxideses, microsomes, benzphetamine N-demethylase, aniline 4-hydroxylase, P-nitrophenol hydroxylase, cytochrome P-450


Emel Arınç, Mesude Iscan, Orhan Adalı, Tülin Güray. Effect of Benzene on Drug Metabolizing Enzyme Activities of Lung and Liver Microsomes. Med J Islamic World Acad Sci. 1988; 1(1): 31-34

Corresponding Author: Emel Arınç, Türkiye


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