ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
Synthesis and Biological Activities of 6-Aryl-1,2,4 Triazolo (3,4-a) Phthalazines and 6-Aryl-Tetrazolo (5,1,-a) Phthalazines [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1990; 3(2): 98-102

Synthesis and Biological Activities of 6-Aryl-1,2,4 Triazolo (3,4-a) Phthalazines and 6-Aryl-Tetrazolo (5,1,-a) Phthalazines

Mohammed A. E. Shaban1, Mamdouh A. M. Taha2, Adel Z. Nasr2
1From Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
2Department of Chemistry, Faculty of Education, Cairo University (Fayoum Branch), Egypt.

Reaction of 1-hydrazino-4-phenylphthalazine and 4-benzyl-1-hydrazinophthalazine with aromatic aldehydes gave the corresponding colored hydrazones. Catalytic dehydrogenative cyclization of these hydrazones afforded the 3,6-diaryl-1,2,4-triazolo (3,4-a) phthalazines. The latter compounds were also obtained from the reaction of 1-chloro-4-phenylphthalazine and 4-benzyl-1-chlorophthalazine with aromatic acid hydrazides. Oxalic and malonic acid dihydrazides reacted with two equivalents of the former imidoyl chloride to give bis-triazolophthalazine derivatives. Reaction of the two imidoyl chlorides with sodium azide gave the corresponding 6-aryl-tetrazolo (5, 1-a) phthalazines. Some of the prepared compounds were tested for their insecticidal and nematicidal activities and found to be inactive.

Keywords: Amidrazones, imidoyl chlorides, triazoles, tetrasoles, phthalazines.


Mohammed A. E. Shaban, Mamdouh A. M. Taha, Adel Z. Nasr. Synthesis and Biological Activities of 6-Aryl-1,2,4 Triazolo (3,4-a) Phthalazines and 6-Aryl-Tetrazolo (5,1,-a) Phthalazines. Med J Islamic World Acad Sci. 1990; 3(2): 98-102

Corresponding Author: Mohammed A. E. Shaban, Egypt


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