ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
A comparative study on C-reactive protein and gamma-glutamyl transferase as novel inflammatory markers of type 2 diabetes mellitus [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2018; 26(4): 87-91 | DOI: 10.5505/ias.2018.22309  

A comparative study on C-reactive protein and gamma-glutamyl transferase as novel inflammatory markers of type 2 diabetes mellitus

Tushar Kanti Bandyopadhyay
purulia Govt. Medical College, purulia, West Bengal, India

Studies in the last few years have linked oxidative stress and inflammation to beta-cell function resulting from chronic exposure to hyperglycemia. Recent prospective trials have suggested that an elevated level of C-reactive protein and gamma-glutamyl transferase enzyme is associated with subsequent development of diabetes. The present study aimed to examine the relationship between gamma-glutamyl transferase and the marker of inflammation C-reactive protein in patients with diabetes. The study was conducted on 300 patients, including 100 healthy controls and 200 patients with type 2 diabetes. Plasma glucose levels (fasting and postprandial), serum levels of high-sensitivity C-reactive protein, levels of glycosylated hemoglobin, and serum gamma-glutamyl transferase hepatic enzyme levels were measured. The mean high-sensitivity C-reactive protein and gamma-glutamyl transferase levels in patients with type 2 diabetes mellitus were significantly higher than the values in controls (P < 0.0010). Further, a significant positive correlation was observed between gamma-glutamyl transferase levels and high-sensitivity C-reactive protein levels in patients with type 2 diabetics (r = 0.312, P = 0.001). The increase in the levels of high-sensitivity C-reactive protein and gamma-glutamyl transferase in patients with diabetes and their significant association might be a result of inflammati on and oxidative stress in diabetes mellitus.

Keywords: C-reactive protein, Gamma-glutamyl transferase, inflammation; oxidative stress, type 2 diabetes


Tushar Kanti Bandyopadhyay. A comparative study on C-reactive protein and gamma-glutamyl transferase as novel inflammatory markers of type 2 diabetes mellitus. Med J Islamic World Acad Sci. 2018; 26(4): 87-91

Corresponding Author: Tushar Kanti Bandyopadhyay, India


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