New Formulations from Acacia Nilotica L. and Glycyrrhiza Glabra L. for Oral Ulcer RemedyDina M. Mostafa1, Nagwa M. Ammar2, Amira A. El-Anssary2, Amany Nemat3, Maha G. Omar4, Sherine A. Nasry5
1Pharmaceutical Technology Department, National Research Centre (NRC), Dokki, Cairo 12622, Egypt.
2Pharmacognosy Department, National Research Centre (NRC), Dokki, Cairo 12622, Egypt.
3Oral Pathology Department, National Research Centre (NRC), Dokki, Cairo 12622, Egypt.
4Oral Medicine and Periodontology Department, College of Oral and Dental Surgery, Misr Univ. for Science and Technology (MUST), 6 th of October City, Egypt.
5Surgery and Oral Medicine Department, National Research Centre (NRC), Dokki, Cairo 12622, Egypt.
This study addresses the innovation of a stable new pharmaceutical formulation comprising natural botanical extracts of Acacia nilotica L. and Glycyrrhiza glabra L., which are therapeutically effective in the treatment of oral ulcer and possess high patient acceptability.Keywords: Acacia nilotica L., Glycyrrhiza glabra L., Adhesive paste, Stability, Oral ulcer
The pastes are prepared, characterized, and subjected to physical and chemical stability studies and then evaluated for therapeutic efficacy regarding ulcer size.
The novel adhesive paste is prepared and when applied to the oral mucosa, it remains on it for a considerable period of time. The stability tests of all the samples in the analysis showed satisfactory physical and chemical stability evaluated by the Normal Stability Test. The mucoadhesive paste incorporating the active; A. nilotica L, when applied to oral ulcer, could promote the healing process, leading to a decrease in diameter of the inflammatory halo of the ulcer. However, the effect of liquorice extract on recurrent aphthous ulceration
(RAU) was found even better than that of acacia extract. A combination of the two plants presented a synergism of both, leading to better healing with favorable reduction of the diameter of inflammatory halo of the ulcer together with a prolonged action.
Therapeutically effective and stable oral pastes are dispensed with cost-effective benefits.
Dina M. Mostafa, Nagwa M. Ammar, Amira A. El-Anssary, Amany Nemat, Maha G. Omar, Sherine A. Nasry. New Formulations from Acacia Nilotica L. and Glycyrrhiza Glabra L. for Oral Ulcer Remedy. Med J Islamic World Acad Sci. 2013; 21(2): 69-76
Corresponding Author: Dina M. Mostafa, Egypt