ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
Safety Tests on Mice and Guinea-Pigs with Bacillus Sphaerıcus Isolate [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1989; 2(4): 264-271

Safety Tests on Mice and Guinea-Pigs with Bacillus Sphaerıcus Isolate

Ayse Bosgelmez, Lütfü Cakmakcı, Selma Yörükan, Naci M. Bor, Nurdan Özer, Bülent Alten, Behzat Gürkan, Öner Koçak, Olus Karayalcın, Feriha Gurkan, Esin Alten
Surgical Research Center, Hacettepe University Medical School, Ankara, Turkiye.

Mammalian toxicity tests were carried out on mice and guinea-pigs with Bacillus sphaericus isolate numbered 3302109 isolated from the Icel region of Turkey. Test animals were injected by various routes, including subcutaneous, intraperitoneal, intravenous, and percutaneous. Also ingestion, inhalation and eye irritation tests were carried out using stock suspension of 2X108 bacteria per/ml for each inoculation. None of the animals showed any evidence of illness, and their behavior, growth and average organ weights were normal.

Keywords: Safety tests, biological control, Bacillus sphaericus.


Ayse Bosgelmez, Lütfü Cakmakcı, Selma Yörükan, Naci M. Bor, Nurdan Özer, Bülent Alten, Behzat Gürkan, Öner Koçak, Olus Karayalcın, Feriha Gurkan, Esin Alten. Safety Tests on Mice and Guinea-Pigs with Bacillus Sphaerıcus Isolate. Med J Islamic World Acad Sci. 1989; 2(4): 264-271

Corresponding Author: Ayse Bosgelmez, Türkiye


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