ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
In-House Preparation and Characterization of Ready-To-Use TC99m-Sn-Macroaggregated Albumin Kit for Lung Perfusion Studies [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1998; 11(4): 131-138

In-House Preparation and Characterization of Ready-To-Use TC99m-Sn-Macroaggregated Albumin Kit for Lung Perfusion Studies

M. Ilyas1, KH H. Haider1, A. Saeeda2, M. Javed2, Z. Shams2, C. Sameera1
1From Faculty of Pharmacy, University of the Punjab, The Mall, Lahore, Pakistan.
2From Institute of Nuclear Medicine (INMOL), Lahore, Pakistan.

Macroaggregates of human serum albumin (HSA) are used as a basis for lung perfusion imaging. The present study involves in-house production of a macroaggregated HSA kit. A modified method for the preparation of Tin-macroaggregated albumin (Sn-MAA) kit, with high Tc99m labeling efficiency (>98%) was developed for lung perfusion studies. The aggregative condition of HSA was stabilized by adding 5 mg/ml polyvinyl pyrolidone (PVP 30, 2.5% solution) and gave a uniform particle size distribution in the range of 10- 60 m. The kits were lyophilized and the stability of both wet as well as lyophilized kits were studied at room temperature 8C and 0C. The results revealed that lyophilized kits were stable for up to six months and retained their particle size uniformity and labeling efficiency. Biodistribution studies in the animals gave excellent lung images, with >90% of the injected radiation dose accumulating in the lungs.

Keywords: Macroaggregated Albumin, Tc99m, human serum albumin (HSA)


M. Ilyas, KH H. Haider, A. Saeeda, M. Javed, Z. Shams, C. Sameera. In-House Preparation and Characterization of Ready-To-Use TC99m-Sn-Macroaggregated Albumin Kit for Lung Perfusion Studies. Med J Islamic World Acad Sci. 1998; 11(4): 131-138

Corresponding Author: KH H. Haider, Pakistan


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