Plasma Thromboxane B2 and Leukotriene B4 Levels in Patients with Coronary Atherosclerosis

Plasma TXB2 and LB4 levels of 17 patients with coronary atherosclerosis were studied prior to bypass surgery. Also correlations between plasma TXB2, LB4 levels and other biochemical parameters including glucose, urea, ALT, AST, LDH, uric acid, cholesterol, triglyceride, platelet count, were investigated in patients with coronary atherosclerosis. Patients with coronary atherosclerosis had increased TXB2 plasma levels as compared with those of control subjects. In contrast, no statistically significant differences were noted for LB4 between control subjects and coronary atherosclerotic patients. TXB2 levels were positively related to serum triglyceride contents and were inversely related to platelet counts and serum LDH levels. In addition, plasma TXB2 levels were positively correlated to plasma LB4 levels. In the present study, serum concentrations of glucose, urea, ALT, AST, uric acid and cholesterol, were not correlated to plasma levels of TXB2 and LB4.