ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
Detection and Characterization of A Heat Stable Bacteriocin (Lactocin Lc-09) Produced by A Clinical Isolate of Lactobacilli [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1999; 12(3): 67-71

Detection and Characterization of A Heat Stable Bacteriocin (Lactocin Lc-09) Produced by A Clinical Isolate of Lactobacilli

Farida Khalid, Roquya Siddiqi, Naheed Mojgani
Department of Microbiology, University of Karachi, Karachi- 75270, Pakistan.

A new bacteriocin lactocin LC-09 produced by Lactobacillus strain LC-09, isolated from a clinical sample, was inhibitory against many species of lactobacilli and other Gram-positive bacteria including Listeria ivanovii, Streptococcus agalactii and S. peyogenes. Characterization of the bacteriocin revealed it to be extremely heat stable (4 hours at 100C) and active at acidic pH values. This bacteriocin was inactivated by protease treatment. Curing of LC-09 with acridine orange, ethidium bromide and by elevated temperature (40C) resulted in mutants defective in bacteriocin production.

Keywords: Heat stable, inhibitory, protease.


Farida Khalid, Roquya Siddiqi, Naheed Mojgani. Detection and Characterization of A Heat Stable Bacteriocin (Lactocin Lc-09) Produced by A Clinical Isolate of Lactobacilli. Med J Islamic World Acad Sci. 1999; 12(3): 67-71

Corresponding Author: Roquya Siddiqi, Pakistan


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