ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 4 Year : 2018
 
Hepatoprotective Effect of Carnosine on Liver Biochemical Parameters in Chronic Ethanol Intoxicated Rat [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2006; 16(2): 77-86

Hepatoprotective Effect of Carnosine on Liver Biochemical Parameters in Chronic Ethanol Intoxicated Rat

Kawther M. Soliman, Manal A. Hamed, Sanaa A. Ali
Department of Medical Biochemistry, Faculty of Medicine, Cairo University and Department of Medicinal Chemistry, National Research Center, Dokki, Cairo, Egypt.

The aim of the present study is to investigate the effect of ethanol and the action of carnosine treatment on certain liver parameters; enzymes, total proteins and glycogen in rats. These enzymes including Krebs cycle enzyme: succinate dehydrogenase (SDH); glycolytic enzymes: lactate dehydrogenase (LDH) and its isoenzymes; glycogenolytic metabolic machineries: glycogen phosphorylase, G-6-Pase and glycogen; hydrolytic enzymes: acid phosphatase (AP) and alkaline phosphatase (ALP); amino acid metabolic enzymes: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and nucleic acid catabolic enzyme: 5`-nucleotidase. The chronic ethanol-intoxicated rats showed a marked disturbance in all the parameters measured, indicating the toxic effect of ethanol by inducing oxidative stress on liver tissue. Administration of carnosine ameliorated the toxic effects of ethanol.

Keywords: Ethanol toxicity, Carnosine, Enzymes, Glycogen.


Kawther M. Soliman, Manal A. Hamed, Sanaa A. Ali. Hepatoprotective Effect of Carnosine on Liver Biochemical Parameters in Chronic Ethanol Intoxicated Rat. Med J Islamic World Acad Sci. 2006; 16(2): 77-86

Corresponding Author: Manal A. Hamed, Egypt


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