ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 26 Issue : 3 Year : 2018
 
Importance of vitamin d level in early-stage chronic lymphocytic leukemia and its comparison with healthy population [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2018; 26(1): 6-9 | DOI: 10.5505/ias.2018.67424  

Importance of vitamin d level in early-stage chronic lymphocytic leukemia and its comparison with healthy population

Mehmet Gunduz, Aysun Ş. Yıkılmaz, Sema Akıncı, İmdat Dilek
Department of Hematology, Atatürk Research and Training Hospital, Ankara, Turkiye

Chronic lymphocytic leukemia (CLL) is a chronic lymphoproliferative hematological malignancy accompanied by a
Chronic lymphocytic leukemia (CLL) is a chronic lymphoproliferative hematological malignancy accompanied by a
monoclonal proliferation of mature B lymphocytes. Vitamin D is vital in calcium hemostasis in serum and skeletal system
and is involved in several other cellular processes such as differentiation, proliferation, apoptosis, and angiogenesis.
Vitamin D receptors were also demonstrated in normal or malignant hematopoietic cells. The correlation of low serum
vitamin D levels with colorectal, breast, and other solid-organ neoplasms is well known. With regard to CLL, vitamin D
inadequacy is related to bad prognosis, bad overall survival, and necessity to start treatment early. This study aimed to
compare vitamin D levels of patients with early-stage CLL and controls and to examine its relationship with prognostic
indicators.
The study included 33 patients with early-stage CLL treated at Atatürk Training and Research Hospital Hematology Clinic
between 2015 and 2017 and 34 healthy controls. Age and gender distribution in both groups was similar. Patients with <20
ng/mL vitamin D level were considered as vitamin D deficient.
Vitamin D deficiency was detected in 26/33 patients with CLL and 16/34 controls. A statistically significant difference in
vitamin D deficiency was found between these two groups (P = 0.003). CLL cases were compared in terms of RAI stage,
splenomegaly, hepatomegaly, and presence of B symptoms. However, no significant difference was observed.
This study demonstrated that vitamin D levels of patients with early-stage CLL were significantly low in comparison with
those of healthy population, in line with the literature. More comprehensive studies are required for assessing the effects
of low vitamin D levels on the prognosis of patients with early-stage CLL.

Keywords: Early-stage CLL, prognosis, vitamin D deficiency


Mehmet Gunduz, Aysun Ş. Yıkılmaz, Sema Akıncı, İmdat Dilek. Importance of vitamin d level in early-stage chronic lymphocytic leukemia and its comparison with healthy population. Med J Islamic World Acad Sci. 2018; 26(1): 6-9

Corresponding Author: Mehmet Gunduz, Türkiye


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