The Effect of Hyperlipidemia on Even-Related Brain Potentials (P3)

The purpose of the study is to investigate cognitive changes in hyperlipidemic patients by means of event-related potentials (ERPs). ERPs of twenty hyperlipidemic patients and age-matched healthy controls were measured by applying infrequent and frequent stimuli as red and green lights respectively. The infrequent stimulus had a 15% probability. ERPs were recorded in two different experimental conditions that the infrequent stimulus was counted (Test 1) or uncounted (Test 2). P3b amplitudes of both groups were decreased significantly in Test 2 compared to Test 1. N2, P3a and P3b latencies of the count stimulus condition (Test 1) were found to be prolonged in the hyperlipidemic group. In addition, peak-to-peak amplitudes of P3b were observed to be decreased (F=5.84, p<0.3).