ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Comparative Effects of Estradiol, Progesterone and Testosterone on The Level of Rat Serum Ceruloplasmin [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1990; 3(2): 143-145

Comparative Effects of Estradiol, Progesterone and Testosterone on The Level of Rat Serum Ceruloplasmin

M. Ani, A. A. Moshtaghie
From Department of Biochemistry, School of Pharmacy, Isfahan University Medical Sciences, Isfahan, Iran.

Ceruloplasmin, a serum alpha-2-globulin with oxidase activity, plays an important role in the metabolism of iron. Following the treatment of animals with the daily doses o 1.6 mg/kg estradiol, 6 mg/kg progesterone and 8 mg/kg testosterone for 15 days, serum ceruloplasmin concentration was elevated 57, and 22 percent respectively. Administration of estradiol for 30, 45 or 60 days led to an increase in the enzyme activity by 92, 77 and 63 percent respectively. Animals receiving either progesterone or testosterone for longer period up to 60 days did not show any significant changes in their serum ceruloplasmin levels. The effects of these steroid hormones on ceruloplasmin activity have been discussed.

Keywords: Ceruloplasmin, estradiol, testosterone, progesterone.


M. Ani, A. A. Moshtaghie. Comparative Effects of Estradiol, Progesterone and Testosterone on The Level of Rat Serum Ceruloplasmin. Med J Islamic World Acad Sci. 1990; 3(2): 143-145

Corresponding Author: M. Ani, Iran


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