ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 1 Year : 2019
 
The Effect of Garlic Oil (Allium Sativum) on Dmba Induced Salivary Gland Tumorigenesis in Rat [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1994; 7(3): 189-192

The Effect of Garlic Oil (Allium Sativum) on Dmba Induced Salivary Gland Tumorigenesis in Rat

M. M. Ziu1, A. S. M. Giasuddin1, A. R. Mohammad2
1From Department of Laboratory Medicine, Faculty of Medicine, Al- Arab Medical University, Benghazi, Libya.
2From Department of Oral Medicine, Faculty of Dentistry, Al-Arab Medical University, Benghazi, Libya.

The chemoprotective effect of garlic oil on 7,12-dimethylbenzanthracene (DMBA) induced carcinogenesis in sub-maxillary salivary glands of male wistar rats was studied. Animals were equally divided into five experimental groups: Group A: Given garlic oil intra peritoneally daily for three weeks prior to DMBA implantation. Group B: Given garlic oil intra peritoneally daily for four weeks after DMBA implantation. Group C: Given DMBA only. Group D: Given daily dose of garlic oil only. Group E: Normal control receiving chow diet only. The histological parameters in sub-maxillary salivary glands and serum beta carotene levels were analyzed at 4, 8 and 12 weeks after DMBA implantation. The histological studies revealed that there was delayed onset and decreased severity of carcinogenesis in Group A, compared to Group B or Group C which showed early onset and extensive carcinogenesis. The serum beta-carotene levels in Group A and B were significantly higher compared to Groups C and E at all levels. Interestingly, Group D had the highest serum betacarotene level, and Group A and Group B had significantly lower serum beta-carotene compared to Group D. The Group A animals had even significantly lower serum beta-carotene levels compared to Group B.
These results indicate that garlic oil may have an adjuvant effect on various defense mechanisms of the host against DMBA-induced carcinogenesis in sub-maxillary salivary glands of rat through increased availability and utilization of beta-carotene. There is evidence that beta-carotene can indeed function as a non-conventional anti-oxidant at low oxygen pressures and thus render protection against cancer by preventing lipid peroxidation in vivo.

Keywords: Garlic oil, tumorigenesis, salivary glands, DMBA.


M. M. Ziu, A. S. M. Giasuddin, A. R. Mohammad. The Effect of Garlic Oil (Allium Sativum) on Dmba Induced Salivary Gland Tumorigenesis in Rat. Med J Islamic World Acad Sci. 1994; 7(3): 189-192

Corresponding Author: A. S. M. Giasuddin, Libya


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