Evaluation of Serum GH, IGF-1, and IGFBP-3 Levels as Biomarkers in The Diagnosis of Acute Myocardial InfarctionHüseyin C. Halhallı1, Yücel Yüzbaşıoğlu2, Kubilay Vural3, Kemal Günaydın4, Figen Coşkun5
1Department of Emergency Medicine, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.
2Department of Emergency Medicine, Yıldırım Beyazit University, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
3Department of Emergency Medicine, Ordu State Hospital, Ordu, Turkey.
4Department of Emergency Medicine, Ankara Training and Research Hospital, Ankara, Turkey.
5Department of Emergency Medicine, Faculty of Medicine Hospital, Kırıkkale University, Kırıkkale, Turkey.
This study aimed to determine the role of the serum growth hormone and insulin-like growth factorbinding proteins 3 levels measured in the first 24 h in the diagnosis and pathophysiology of acute myocardial infarction (AMI). Keywords: Acute myocardial infarction, GH, IGF-1, IGFBP-3
The levels of serum Growth hormone, insulin-like growth factors1, and insulin-like growth factorbinding proteins 3 of the patients diagnosed with AMI in the first 24 h of onset and that of the control group at the time of admission were compared between January 1 and August 31, 2010.
The average age of the patient group was 59.36 ± 13: 25 years, and 79.4% of the patients were males. The serum growth hormone and insulin-like growth factorbinding proteins 3 levels were significantly higher in the patient group (P < 0.05). However, no differences were found between insulin-like growth factors 1 levels in both the groups (P > 0.05). The sensitivity of growth hormone was 84.1% with a cutoff value of 0.14; the sensitivity of insulin-like growth factors1 was 33.6% with a cutoff value of 162; and the sensitivity of insulin-like growth factorbinding proteins 3 was 75.7% with a cutoff value of 2862.
The present study showed that growth hormone and insulin-like growth factor binding proteins 3 markers play important roles in the pathophysiology of myocardial infarction. Hence, it is thought that they can be used in the diagnosis of AMI. Further studies are needed to validate the conclusion.
Hüseyin C. Halhallı, Yücel Yüzbaşıoğlu, Kubilay Vural, Kemal Günaydın, Figen Coşkun. Evaluation of Serum GH, IGF-1, and IGFBP-3 Levels as Biomarkers in The Diagnosis of Acute Myocardial Infarction. Med J Islamic World Acad Sci. 2016; 24(3): 77-82
Corresponding Author: Hüseyin C. Halhallı, Türkiye