ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 2 Year : 2019
 
Synthesis and Antibacterial Activity of Picoline Derivatives [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1994; 7(1): 26-29

Synthesis and Antibacterial Activity of Picoline Derivatives

M. Saeed1, Saire Hameed3, Abdullah Khan1, Mansoor Ahmed1, S. S. Nizami2, M. H. Kazmi3
1From Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
2From Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
3From Department of Applied Chemistry, University of Karachi, Karachi-75270, Pakistan.

Six different phenacyl halide derivative of -picoline were synthesized and studied for their antibacterial activity against twenty four gram negative and twelve gram positive microorganisms. Compound I, III and IV showed almost broad spectrum activity, whereas rest of three compounds did not exhibit so promising results. Spectroscopic techniques, such as 1H-NMR, EIMS, UV and IR spectroscopy were utilized for their structure elucidation.

Keywords: -picoline, phenacyl halides, antibacterial.


M. Saeed, Saire Hameed, Abdullah Khan, Mansoor Ahmed, S. S. Nizami, M. H. Kazmi. Synthesis and Antibacterial Activity of Picoline Derivatives. Med J Islamic World Acad Sci. 1994; 7(1): 26-29

Corresponding Author: Saire Hameed, Pakistan


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