ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
Volume : 27 Issue : 3 Year : 2019
Med J Islamic World Acad Sci: 18 (1)
Volume: 18  Issue: 1 - 2010
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1.The Study of A New Method in Treatment of Term Newborns with Non-Hemolytic Hyperbilirubinemia
Nader Pashapour, Ali Maccoei, Sariyeh G. Iou, Hossein Akhondi
Pages 5 - 8
The purpose of the study was to determine whether reduction of serum levels of bilirubin is more in full-term newborn with non-hemolytic hyperbilirubinemia that treated with new treatment than in matched control subjects.
Eighty consecutively admitted term healthy neonate with indirect hyperbilirubinemia and indication for phototherapy were randomized into receiving phenobarbital (3 mg/kg/day) plus phototherapy as new treatment method or phototherapy as routine method after obtaining informed consent. The neonate followed up until discharge. The total serum bilirubin levels were measured four times a day. Patient's data regarding variation of bilirubin and hospitalization duration collected and compared from the two groups. Results are presented as the mean, 95% confidence interval, 0.05% significance level and 80% power.
The baseline characteristics were similar in two groups. Mean ages were 5.5 ± 2.81 and 4.80 ± 1.68 days for control and case group respectively. Mean bilirubin levels in admission were 19.48 ± 2.80 mg/dl and 18.51 ± 1.66 for control and case group respectively. There was significant reduction of bilirubin levels in case group compared to control group (10.54 ± 3.00mg/dl versus 8.60 ± 1.99 mg/dl) (P=0.001). No significant difference with respect to duration of hospitalization was observed in two groups' (2.05 ± 0.59 days for control versus, 2.15 ± 0.80 days for case group).
In despite of significant reduction of bilirubin levels in case group compared to control group, combined treatment is not helpful in reducing of hospitalization days of non hemolytic hyperbilirubinemia in healthy term neonates.

2.Para-Clinical Evaluation of Taxane Side Effects on Auditory System (PTA-Treshold)
Mozaffar S. Afraz, Khashayar Ahmadi
Pages 9 - 12
Ototoxicity is one of the major causes of hearing loss and balance system disorders.Taxans are new of anti-neoplastic agents chemotherapy with these agents include Paclitaxel and Docetaxel. In this study we have been evaluated ototoxicity of these drugs to adjust dose if necessary to avoide their complications. This is a study of 103 known cases of breast and ovarian cancer with mean age 45 ± 2.3 years during may 2004 to jun 2006 (20 months) in Ahwaz That were treated with Taxans (in a 20 months period).The first evaluation of hear ing (with PTA) was performed before initiation of treatment and the second was performed at the middle of treatment period and the last one at the end of treatment. Nausea and vomiting was the most common side effect of these drugs in this study. We did not any significant side effects of taxanes on audiovestibular system. There is few information about ototoxicity effect of Taxanes in the other studies, and we did not find any significant effect on Auditory system in the PTA standard ( 0/5 - 8 KHZ).

3.Impact of Intake of Plant Foods’ Iron on The Recovery from Iron Deficiency in Rats
Thanaa E. Hamed, Doha A. Mohamed, Abeer A. Afifi, Sahar Y. Al-okbi
Pages 13 - 20
In the present research, two iron concentrates prepared from fruit and vegetable juices in addition to other plant foods products expected to be rich in iron and nutrients that enhance iron absorption have been chemically and biologically evaluated. Iron and Zn and other mineral and phytochemicals that have been claimed to reduce iron absorption (Ca, polyphenols and tannins) and micronutrients that reported to enhance iron absorption (Vitamin C, toccopherols and carotenoids) have been determined. The efficiency and safety of iron concentrates were evaluated in iron deficiency model of rats.
The iron concentrates have been shown to contain variable levels of Fe, Zn, Ca, polyphenols, tannins, vitamin C, toccopherols and carotenoids. The sum of promoters and inhibitors in mixture 1 was higher than that in mixture 2. The two iron concentrates showed improvements of iron status, however mixture 2 (3.5 strawberry: 3.5 pomegranate: 1 blackstrap: 0.5 carrot: 0.5 pumpkin: 1 orange in addition to 10% lettuce juice) was more efficient than mixture 1 (4.7 strawberry: 2.7 beetroot: 1.3carrot: 1.7 guava in addition of 1.3%wheat germ oil and 3.3%lettuce juice). Iron deficiency anemia induced oxidative stress which was reduced on supplementation of the iron concentrates. Both iron concentrates showed safety concerning liver and kidney functions.

4.Glucose Tolerance Test in Hyperglycemic Guinea Pigs Treated with Aqueous Vernonia Amygdalina
Ibiba F. Oruambo, Ezinne O. Onuba, Susan D. Anyim
Pages 21 - 26
We have determined the comparative response in hyperglycemic guinea pigs to a glucose tolerance test (GTT) following treatment with either unboiled or boiled aqueous extract of Vernonia amygdalina (bitter leaf ) or glucophage solution. The animals were divided into four groups, fasted overnight and each received glucose solution by intraperitoneal injection (ip.) following fasting to induce hyperglycemia. One group served as control, the second group received unboiled extract of bitter leaf, the third group received boiled extract of bitter leaf, while the fourth group received a glucophage solution all by i.p. Following treatment, blood samples were collected from each group at 30 min, 60min, and 180 min and glucose concentration was determined in each sample by the glucose oxidase method.
The results show that at 30 min, control blood glucose level spiked to 17.4 mmol/L from a Fasting Blood Glucose level of 5.6mmol/L; at 60 min, the level dropped to 8.1 mmol/L and then stabilized to Fasting (Baseline) level of 5.5 mmo/L at 180min. This curve (pattern) is consistent with classical GTT protocol. In the GTT pattern of animals treated with unboiled aqueous bitter leaf extract (b.l.e), blood glucose level rose to 9.8 mmol/L at 30min, nose dived to 5.7 mmol/L at 60min (a Baseline value), and stabilized at 5.6mmol/L after 180min. On the other hand, in the GTT pattern of the boiled aqueous b.l.e. and glucophage solution, excess blood glucose was not cleared to Baseline (control) level even after 180 min: for boiled b.l.e, blood glucose level rose to 12.9 mmol/L at 30 min, dropped to 6.7 mmol/L and stabilized at 6.2 mmol/L at 180 min, a level higher than baseline. Similarly, for glucophage, a spike of blood glucose level of 13.1 mmol/L occurred at 30 mins, (near identical with boiled b.l.e), dropped to 7.2 at 60 min (higher than unboiled b.l.e) and increased to 9.5 mmol/L after 180 min (similar pattern to boiled b.l.e).
These results clearly show that under these GTT conditions, the unboiled water b.l.e. cleared the excess blood glucose molecules more rapidly and more quantitatively than either the boiled water b.l.e. or glucophage, and therefore may be a more effective antihyperglycemic preparation.

5.Unani System of Medicine - Introduction and Challenges
Ahmad Husain, G. D. Sofi, Tajuddin Tajuddin, Raman Dang, Nilesh Kumar
Pages 27 - 30
The Unani System of Medicine pioneered in Greece and was developed by Arabs into an elaborate medical science based on the frame work of the teaching of Buqrat (Hippocrates) and Jalinoos (Galen). Since that time Unani Medicine has been khown as Greco-Arab Medicine. This system is based on Hippocatic theory of four humours viz. blood, phlegm, yellow bile and black bile, and the four qualities of states of living human body like hot, cold, moist and dry. They are represented as earth, water, fire and air, the Greek ideas were put by Arabian physician as seven principles (Umoor-e-Tabbiya) and included, element (Arkan), temperament (Mizaj), humours (Akhlat), organs (Aaza), sprit (Arwah), faculties (Qowa) and functions (Afaal). In this system is it believed that, these principles are responsible for the body constitution and its health, as well as, diseased
conditions (1).
The World Health Organization (WHO) has recognized the Unani System of Medicine (USM) as an alternative system to cater the health care needs of human population. Alternative medicine is being practiced worldwide.

6.Levels of Trace Elements in Commercial Fruit Juices in Jeddah, Saudi Arabia
S. M. Farid, M. A. Enani
Pages 31 - 38
Potable water, fruit juices and soft drinks are some of the most widespread beverages in the habitual diet, and they can contribute to trace element dietary intake. Heavy metals' toxicity is the result of their interactions with the enzymatic systems from the animal cells or some constituents of cells' membranes. Population can be contaminated with heavy metals by ingestion of contaminated or polluted food and water. The concentration of heavy metals in food products is varied, depending on their origin, storage conditions and processing technologies.
We determined the concentrations of zinc(Zn), copper(Cu), iron(Fe), chromium(Cr), manganese(Mn), cobalt(Co) and nickel(Ni) in apple, orange and mango fruit juice samples of 15 different brands widely consumed in Saudi Arabia. Graphite furnace atomic absorption spectrometry was used to analyze fruit juice samples processed with a HNO3 -V2O5 acid digestion. In analyzed Samples, the mean (±SD) concentration values in ppb of Zn, Fe, Cu, Mn, Co, Cr, and Ni in apple juice are: (524.00±43.06); (325.36±23.12);(317.79±21.56); (23.48±2.23); (8.07±0.95); (6.36±0.94); and (6.21±0.90) respectively.
The mean (±SD) concentration values in ppb of Zn, Fe, Cu, Mn, Co, Cr, and Ni in orange juice are: (894.80±45.21); (361.27±24.11); (500.00±38.88); (20.93±2.36); (7.93±1.02);(5.93±0.92) and (5.73±0.91) respectively. Finally, the mean (±SD) concentration values in ppb of Zn, Fe, Cu, Mn, Co, Cr, and Ni in mango juice are: (486.57±35.25); (463.50±32.67); (461.07±29.49); (21.85±2.58); (8.14±1.28); (7.64±1.02) and
(5.93±0.96) respectively. Our results for fruit juice are compared with Recommended Dietary Allowance (RDA) values and also with the corresponding values of different countries available in literature.

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