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The Mechanism of Manganese Induced Learning Disability [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1992; 5(1): 49-52

The Mechanism of Manganese Induced Learning Disability

Gülsen Öner, Ümıt K. Şentürk
From Akdeniz University, Faculty of Medicine, Department of Physiology, Antalya, Türkiye.

To determine the mechanism by which manganese induces learning defect in human and animals, we carried out an experimental study using two months old female rats which were exposed daily 357 g of manganese for 30 days. Manganese induced a significant increase in the cholesterol of blood and brain tissues. An obvious elevation in hippocampal cholesterol was associated with an impaired learning in rats exposed to manganese. Preventing the cholesterol biosynthesis with a drug which inhibits the biosynthesis of cholesterol, the manganese induced learning disability corrected completely. This correction led us to conclude that manganese by increasing hippocampal cholesterol levels impairs learning ability.

Keywords: Manganese, learning ability, cholesterol.

Gülsen Öner, Ümıt K. Şentürk. The Mechanism of Manganese Induced Learning Disability. Med J Islamic World Acad Sci. 1992; 5(1): 49-52

Corresponding Author: Gülsen Öner, Türkiye

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