The Effect of Long-Term Parenteral Nutrition of Dogs On The Hepatobiliary System

Dogs were subjected to paranteral nutrition with hypertonic glucose and aminoacids for 31 days. During the first ten days there was no significant alteration in liver function tests. The serum cholesterol began to increase on the 11th and SGPT began to increase on the 21st day. Total protein and albumin levels exhibited respective decrease. By the 31st day the rates of increase was 199.6 % for SGOT, % for SGPT, 37.3% for cholesterol, 24.4% for total lipid, 113.2% for alkaline phosphatase and 65.6% for direct bilurubine. The body weight and blood sugar showed no significant change. Marked cholestasis was detected on histopathological examination. Electron microscopic studies revealed increase in the number of the biliary canalicules and presence of inclusion bodies such as dense lipids
and lysosomes within the hepatocytes.