ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Evaluation of The Anti-Diabetic Effect of Aqueous Leaf Extract of Tapinanthus Butungii in Male Sprague-Dawley Rats [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2006; 16(1): 41-47

Evaluation of The Anti-Diabetic Effect of Aqueous Leaf Extract of Tapinanthus Butungii in Male Sprague-Dawley Rats

A. A. Osinubi1, O. G. Ajayi2, A. E. Adesiyun3
1Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria.
2Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.
3Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.

The prevalence of diabetes mellitus is between 2-7% of the population, increasing with age to between 10-14% of the patients aged above 40 years. Despite significant achievements in treatment modalities and preventive measures, the prevalence of diabetes has risen exponentially in the last decade. There is therefore a continued need for new and more effective therapies. Our aim was to evaluate the hypoglycemic, anti-hyperglycemic and anti-diabetic effects of aqueous extract of fresh green leaves of Tapinanthus butungii in rats.
Young adult, male Sprague-Dawley rats weighing 180-200 g were used. Diabetes mellitus was induced in the group of diabetic test rats by intraperitoneal injections of alloxan (150 mg/kg). Hyperglycemic state was induced by administration of subcutaneous injections of 50% Dextrose in water (5 g/kg). Single doses of aqueous leaf extract of Tapinanthus butungii (200, 300 or 400 mg/kg p.o.) were administered to normoglycemic, hyperglycemic and diabetic rats. The hypoglycemic, anti-hyperglycemic and anti-diabetic effects of these single doses were compared with those of glibenclamide (10 mg/kg), chlorpropamide (250 mg/kg), insulin lente (0.1 I.U./kg) and distilled water (2 ml/kg). Blood glucose levels were estimated before treatment, 0h, 1h, 2h, 4h, 8h, 10h and 12h after administration of extract.
Aqueous leaf extract of Tapinanthus butungii produced significant dose-dependent reductions (p < 0.05-0.001) in blood glucose concentrations of normoglycemic, hyperglycemic and diabetic rats comparable to glibenclamide, chlorpropamide and insulin.
Our results suggest that the leaves of Tapinanthus butungii have strong and remarkable anti-diabetic properties. Further studies are, however, required on the characterization of the constituents of the leaf extract of Tapinanthus butungii.

Keywords: Tapinanthus butungii, blood glucose, diabetes mellitus.


A. A. Osinubi, O. G. Ajayi, A. E. Adesiyun. Evaluation of The Anti-Diabetic Effect of Aqueous Leaf Extract of Tapinanthus Butungii in Male Sprague-Dawley Rats. Med J Islamic World Acad Sci. 2006; 16(1): 41-47

Corresponding Author: A. A. Osinubi, Nigeria


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