Aluminium Administration on Acetylcholinestrase Activity of Different Regions of Rat Brain

The present investigation was undertaken to study short and long term effects of aluminium on acetylcholinestrase activity of different areas of rat brain.
Intraperitoneal administration of 2 mg/kg aluminium as AlCl3 daily for 15 to 60 days reduced acetylcholinestrase activity of cerebellum controls from 16.3 ± 0.7 to 14.2 ± 0.9, mid-brain from 15.8 ± 0.7 to 12.3 ± 0.7 and brain cortex from 8.7 ± 0.7 to 1.0 ± 0.4 mole enzyme/mg protein/min respectively (p < 0.05). Aluminium (10 mg/kg) administration daily for 15 and 30 days reduced acetylcholinestrase activity of cerebellum controls from 16.2 ± 0.8 to 12.1 ± 1.0, mid-brain from 15.8 ± 0.4 to 9.6 ± 0.5 and brain cortex from 8.4 ± 0.6 to 5.4 ± 0.4 mole enzyme/mg protein/min respectively (p < 0.05). Serum aluminium of aluminium treated animals was elevated significantly (p < 0.05). The neurotoxicity of aluminium has been considered in the discussion.