Genetic Activity of Certain Chemicals in Salmonella-Microsomal Screening SystemSheikh A. Rasool, Roohi MushtaqFrom Department of Microbiology, University of Karachi, Karachi- 75270, Pakistan.
The Ames Salmonella typhimurium microsomal screening system was standardized and six alkaloids and a mosquito repellent were screened for their mutagenic potential. The results indicated that mosquito repellent and all the six (buxenone, ephedradine, protopine, saponin, pleiocarpamine and vindoline) alkaloids exhibited mutagenic activity (based on his -‡his+ reversions, in TA98 tester strain. In addition, vindoline also induced reversion mutations in TA100. Keywords: Ames test, salmonella, microsomal system, alkaloids.
Sheikh A. Rasool, Roohi Mushtaq. Genetic Activity of Certain Chemicals in Salmonella-Microsomal Screening System. Med J Islamic World Acad Sci. 1991; 4(4): 301-304
Corresponding Author: Sheikh A. Rasool, Pakistan |
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