ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
Volume : 27 Issue : 3 Year : 2019
G-6-Pd Çorum: A New Variant of Glucose -6- Phosphate Dehydrogenase [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1989; 2(1): 31-33

G-6-Pd Çorum: A New Variant of Glucose -6- Phosphate Dehydrogenase

M. Sezai Kus
From Department of Biochemistry, University of Hacettepe, Faculty of Medicine, Hacettepe, Ankara, Turkiye.

A new variant of glucose-6-phosphate dehydrogenase (G-6-PD) is reported. Severe enzyme deficiency (1% of normal) was found in a 16-year-old Turkish school boy. This enzyme deficiency was associated with chronic haemolytic anaemia. The partially purified enzyme had a slow electrophoretic mobility in both polyacrylamide slab gel and cellulose acetate strip system, normal Km for G-6-P, decreased Km for NADP+, normal heat stability, biphasic pH curve and slightly increased utilization of 2-deoxy glucose-6-P, galactose-6-p, and deamino-NADP+. The utilization of NAD+ by the variant enzyme was increased sixfold. The variant is named G-6-PD Çorum, after the place of origin.

Keywords: Glucose-6-phosphate dehydrogenase, Glucose-6-phosphate dehydrogenase deficiency, Glucose-6-phosphate dehydrogenase variant, Haemolytic anaemia.

M. Sezai Kus. G-6-Pd Çorum: A New Variant of Glucose -6- Phosphate Dehydrogenase. Med J Islamic World Acad Sci. 1989; 2(1): 31-33

Corresponding Author: M. Sezai Kus, Türkiye

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