The Immunosuppressive Effect of Bromocriptine in Rats

In order to investigate the role of bromocriptine (BCR) on immune response we have undertaken an experimental study and its results were compared with those of another immunosuppressive agent, Cyclosporine A (CsA). 63 mole Swiss albino rats were divided into 4 groups. Twenty two of those were used as a control and received intraperitoneal saline for 4 days. The other groups were treated with 3 mg/Kg CsA, 200 g/Kg of BCR and the combination of these two drugs for the same period. CsA treatment caused significant decrease in T cell proliferation and macrophage phagocytic activity, BCR showed similar depression both in the response of T cell and phagocytic activity. However the combination of these two drugs showed no additive effect on immune system. As a conclusion, a PRL secretion inhibitor BCR has been found to be a potent immunosuppressive agent which is comparable to CsA.