Clinical, Biochemical and Histopathological Findings and Long-Term Prognosis in Mesangiocapillary Glomerulonephritis

In this study, three years follow-up of 26 patients with mesangiocapillary glomerulonephritis (MCGN) was assessed. First group consisted of 15 patients (mean age 30.0±13.6); whose proteinuria became negative and serum creatinine levels dropped below 2 mg/dl at the end of 3 years. Group II included 11 patients whose proteinuria continued and renal functions did not improve or deteriorated (Mean age 23.2±8.8). In three patients of group II end-stage renal disease developed in 6th, 12th and 24th months and the remaining patients of this group showed decreased renal function and/or continued proteinuria. During the first assessment in Groups I and II, the rate of nephrotic syndrome 60% (9/19) and 72% (8/11), hypertension 53% (8/15) and 63% (7/11) was noticed.
In preliminary evaluation the prognostic factors were the presence on renal biopsies of tubulointerstitial changes (TIC) (27% and 80% groups I and II), vascular involvement (18.2% and 90% Groups I and II), glomerulosclerosis (9.1% and 60%). In the group II with poor prognosis creatinine clearance (Ccr) was lower and leukocyte count was higher compared to group I, whereas statistically significant differences were not found.
As a result; Among our 26 patients with MCGN the complete recovery from disease was 57.6%, and the factors which influenced the prognosis at the beginning of the process were renal biopsy findings including the presence of glomerulosclerosis, vascular involvement (VI) and tubulointerstitial changes (TIC), rather than biochemical and clinical signs.