ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
Volume : 27 Issue : 3 Year : 2019
Splenic Functions in Thalassemia Major [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2015; 23(1): 28-32

Splenic Functions in Thalassemia Major

Şinasi Özsoylu1, Yahya Laleli2, Güner Müniboğlu3
1Retired Professor of Pediatrics, Hematology and Hepatology, Honorary Fellow of American Academy of Pediatrics, Honorary Member of American Pediatric Society, Honorary Member of Turkish Academy of Sciences, Fellow of Islamic World Academy of Sciences, Ankara, Turkey
2Prof of Biochemistry and Nuclear Medicine.

Platelet and factor VIII (F-VIII) storage and phagocytic functions of the spleen were studied in 15 patients with -thalassemia major who were not splenectomized and in 7 patients with Hb-S-b-thalassemia. Eight splenectomized patients, 4 patients with b-thalassemia major, and 11 healthy children served as controls. F-VIII elevation following adrenalin was not found to be a sensitive index in the evaluation of “functional hyposplenia.” No fuctional derangement of the organ was shown in the patients with b-thalassemia major. However, one of the tests showed that at least 30% of the patients had functional hyposplenism. Higher platelet counts were observed in the patients without palpable spleen, and the independence of the splenic functions were shown.

Keywords: Thalassemia splenic functions

Şinasi Özsoylu, Yahya Laleli, Güner Müniboğlu. Splenic Functions in Thalassemia Major. Med J Islamic World Acad Sci. 2015; 23(1): 28-32

Corresponding Author: Şinasi Özsoylu, Türkiye

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