ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Safety Tests on Mice and Guinea-Pigs with Bacillus Thuringiensis Israelensis [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1990; 3(1): 41-48

Safety Tests on Mice and Guinea-Pigs with Bacillus Thuringiensis Israelensis

Nurdan Özer, Selma Yorukan, Lutfu Cakmakci, Ayse Bosgelmez, Bulent Alten, Behzat Gurkan, Oner Kocak, Feriha Gurkan, Olus Karayalcın, Esin Alten, Gönül Çetinkaya, Naci M. Bor
Scientific and Technical Research Council of Turkey (TOAG-TARMIK) and was conducted at the Surgical Reseach Center, Hacettepe University Medical School, Ankara, Türkiye.

Mammalian toxicity tests were carried out on mice and guinea-pigs with Bacillus thuringiensis israelensis number 330211, isolated from the Icel region of Turkey. Test animals were injected by various routes including subcutaneous intraperitoneal, intravenous, oral, percutaneous, inhalation and eye irritation test, using stock suspension of 2X108 per/ml bacteria for each inoculation. None of the animals showed any evidence of illness and behaviour, growth, average organ and body weights were normal.

Keywords: Safety tests, mice, guinea-pig, biological control, Bacillus thuringiensis israelensis.


Nurdan Özer, Selma Yorukan, Lutfu Cakmakci, Ayse Bosgelmez, Bulent Alten, Behzat Gurkan, Oner Kocak, Feriha Gurkan, Olus Karayalcın, Esin Alten, Gönül Çetinkaya, Naci M. Bor. Safety Tests on Mice and Guinea-Pigs with Bacillus Thuringiensis Israelensis. Med J Islamic World Acad Sci. 1990; 3(1): 41-48

Corresponding Author: Nurdan Özer, Türkiye


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