Trail to Induce Psoriatic Skin Lesion in The Skin of Balb/C Mice by Injection of Staphylococcus Aureus ExotoxinHanadi A. Jassim1, Sundus S. Bakr1, Khalil I. Hamdi21Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq.
2Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq.
An In Vivo attempt to induce psoriatic lesions in the skin of BALB/C mice by injection of bacterial superantigen.
Staphylococcus aureus that was isolated from skin lesions of psoriatic patients was subjected to gel filtrations chromatography for extraction and purification of their exoproteins. The skin of BALB/C mice was injected by 0.2 ml of the extracted purified exotoxin.
The induced lesions were markedly similar to that of human psoriatic lesions, although the histopathological changes were not completely mirrored to that of human psoriatic skin lesions.
There is an important role of Staph. aureus exotoxine (superantigen) in induction, triggering and maintenance of psoriatic lesions. Keywords: Staphylococcus aureus, psoriasis, superantigens, animal model.
Hanadi A. Jassim, Sundus S. Bakr, Khalil I. Hamdi. Trail to Induce Psoriatic Skin Lesion in The Skin of Balb/C Mice by Injection of Staphylococcus Aureus Exotoxin. Med J Islamic World Acad Sci. 2013; 21(4): 163-172
Corresponding Author: Hanadi A. Jassim, Iraq |
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