Reaction Products of Thiosemicarbazide with 1, 5-Diarylpent-1-Yne-3, 5-DionesMohamed G. Marei, Moneim El-GhanamFrom Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia P.O. Box 426, Alexandria 21321, Egypt.
Acetylenic ß-diketones reacted with thiosemicarbazide to give either 6H or 3H, 6Hpyrazolo [1, 5-c] pyrimidinethiones depending on the nature of the substituents as well as the reaction conditions. The reaction of 2-aryl-5-phenyl-6H-pyrazolo [1, 5-c] pyrimidine-7-thiones with nitrous acid and benzenediazonium chloride gave the corresponding disulfide and phenylazo disulfide derivatives, respectively. With certain electrophiles, 3-substituted-7-thiones are formed. Moreover, oxidation with alkaline hydrogen peroxide afforded the respective pyrazolopyrimidinones. Keywords: Thiosemicarbazide, 5-diarylpenth-1-yne-3, 5-diones.
Mohamed G. Marei, Moneim El-Ghanam. Reaction Products of Thiosemicarbazide with 1, 5-Diarylpent-1-Yne-3, 5-Diones. Med J Islamic World Acad Sci. 1992; 5(2): 86-92
Corresponding Author: Mohamed G. Marei, Egypt |
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