ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Synthesis of Some New Heterocyclic Compounds with Expected Potential Biological Activity [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1989; 2(2): 135-138

Synthesis of Some New Heterocyclic Compounds with Expected Potential Biological Activity

O. M. O. Habib, E. B. Moawad, S. S. El-Morsy
From the Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.

Benzenesulphonate of p-hydroxybenzaldehyde reacts with hippuric acid in the presence of acetic anhydride and sodium acetate to give 4-(benzylidene-4-benzenesulphonate)-2- phenyl -2- oxazolin-5- one II. Reaction of II with chloroaniline or o-phenylenediamine in ethyl alcohol afforded the corresponding arylcarboxamides of -arylcarb-oxamido-cinnamic acids III a, b. When the reaction was carried out in acetic acid containing sodium acetate the products were the imidazolone IV and benzimidazole V derivatives. Under the same conditions II reacts with p-phenylenediamine to give the bis-imidazolone VI derivative. Also II undergoes addition reactions with piperidine and thiophenol to yield the addition products VII a, b. Michael reaction of ethyl cyanoacetate with II affords compound VIII.

Keywords: Heterocyclic compounds, biological activity, oxazole derivatives


O. M. O. Habib, E. B. Moawad, S. S. El-Morsy. Synthesis of Some New Heterocyclic Compounds with Expected Potential Biological Activity. Med J Islamic World Acad Sci. 1989; 2(2): 135-138

Corresponding Author: O. M. O. Habib, Egypt


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