ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Aluminum Distribution in Rat Liver Sub-Cellular Fractions in Relation to Neurological Disease in Hemodialyzed Patients [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1994; 7(4): 215-220

Aluminum Distribution in Rat Liver Sub-Cellular Fractions in Relation to Neurological Disease in Hemodialyzed Patients

A. A. Moshtaghie
From Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

The distribution of aluminum within the sub-cellular fractions of rat liver was investigated. The majority of the aluminum was bound to nuclei and mitochondria. The aluminum content of nuclei and mitochondria was 5.2 and 4.9 g per gram protein respectively. Lysosomes, cytosol and microsomes contained 3.75, 1.12 and 0.86 g aluminum per gram protein, respectively. In the nuclei the majority of aluminum was in the non-DNA compartment of nucleoprotein and SDS-PAGE showed that histones could bind aluminum. The relationship between aluminum toxicity and neurological disorders in chronic renal failure maintained on hemodialysis has been discussed.

Keywords: Aluminum, hemodialyzed patients, sub-cellular localization.


A. A. Moshtaghie. Aluminum Distribution in Rat Liver Sub-Cellular Fractions in Relation to Neurological Disease in Hemodialyzed Patients. Med J Islamic World Acad Sci. 1994; 7(4): 215-220

Corresponding Author: A. A. Moshtaghie, Iran


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