ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Antineoplastic Activities of Acetone Thiosemicarbazone against Ehrlich Ascites Carcinoma Cells Bearing Mice [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2013; 21(3): 97-104

Antineoplastic Activities of Acetone Thiosemicarbazone against Ehrlich Ascites Carcinoma Cells Bearing Mice

Mohammud M. Ali, Mele Jesmin, Mohammud K. Islam, Fatema Khatun, Abul K. Azad
Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Bangladesh.

A schiff base acetone semicarbazone has been synthesized and characterized. Its anticancer activities have been studied against Ehrlich Ascites Carcinoma (EAC) cells in swiss albino mice by monitoring the parameters like tumour cell growth inhibition, tumour weight, survival time, peritoneal cells and haematological parameters. It was found that this compound significantly reduces tumour cell growth rate, decreases tumour weight and increases life span in comparison to those of EAC bearing mice. The test compound restored the depleted haematological parameters of EAC bearing mice towards normal. The compound also enhanced number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin.

Keywords: Anticancer activity, EAC cell, Schiff base, Acetone thiosemicarbazone.


Mohammud M. Ali, Mele Jesmin, Mohammud K. Islam, Fatema Khatun, Abul K. Azad. Antineoplastic Activities of Acetone Thiosemicarbazone against Ehrlich Ascites Carcinoma Cells Bearing Mice. Med J Islamic World Acad Sci. 2013; 21(3): 97-104

Corresponding Author: Mohammud K. Islam, Bangladesh


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