ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Lipoprotein(A) as A Strong Risk Factor for Coronary Artery Disease in Iranian Population [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2000; 13(1): 5-9

Lipoprotein(A) as A Strong Risk Factor for Coronary Artery Disease in Iranian Population

Beman A. Jalali1, M. Rafie2, H. Mozaffari3
1Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.
2Department of Cardiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.
3Department of Nutrition, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.

Lipoprotein(a) [Lp(a)] a cholesterol rich particle in human plasma, is a risk factor for coronary artery disease (CAD). The aim of present study was to determine and compare serum Lp(a) in the CAD patients with normal healthy volunteers in Iranian population.
This investigation included 117 patients (25 females, 92 males) with different degrees of coronary stenosis and 103 normal subjects (51 females, 52 males). Blood samples were collected in the morning after an overnight fasting and sera were stored at -20C until the Lp(a) assay. The lipids and lipoproteins were measured by enzymatic methods and Lp(a) assay was done by electroimmunodiffusion.
The results showed that the serum Lp(a) did not correlate significantly with age, sex and other lipid risk factors. The Lp(a) levels in CAD group with a mean of 4140 mg/dl were significantly higher than controls with a mean of 25.528 mg/dl (p<0.001).
We conclude that Lp(a) is an independent risk factor for atherosclerotic coronary artery disease in the Iranian population.

Keywords: Coronary artery disease, lipoprotein(a).


Beman A. Jalali, M. Rafie, H. Mozaffari. Lipoprotein(A) as A Strong Risk Factor for Coronary Artery Disease in Iranian Population. Med J Islamic World Acad Sci. 2000; 13(1): 5-9

Corresponding Author: Beman A. Jalali, Iran


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