On The Nature of Correlation between Plasma Proteins

This study was conducted to determine the nature of correlation between plasma proteins in healthy individuals. Blood samples were collected from children, male and female adults, and using rate nephelometry plasma albumin, transferrin, 1-antitrypsin, group specific component (Gc protein) and three immunoglobulins, IgG, IgM, and IgA were estimated in each sample. Each protein was subjected to regression analysis with each of the other proteins and correlation coefficients were determined.
A statistically significant (p<0.007) positive correlation was obtained between each of the proteins in the children, except between Gc protein and the other six plasma proteins investigated. While in adults the results were different for IgA and IgM when compared with those for the children.
In this paper we present the results of regression analysis and correlation coefficients between seven plasma proteins in children and adults and discuss their possible causes and significance.